Fig. 8: Schematic illustration of a potential role for eNAMPT in hypothalamic circadian regulation of locomotor activity. | Nature Communications

Fig. 8: Schematic illustration of a potential role for eNAMPT in hypothalamic circadian regulation of locomotor activity.

From: Circulating blood eNAMPT drives the circadian rhythms in locomotor activity and energy expenditure

Fig. 8: Schematic illustration of a potential role for eNAMPT in hypothalamic circadian regulation of locomotor activity.The alternative text for this image may have been generated using AI.

Light and food availability control eNAMPT secretion from the liver or leukocytes to systemic circulation in a circadian manner. Blood eNAMPT acts upon the hypothalamus to drive circadian rhythms in locomotor activity via hypothalamic NAD+–SIRT–FOXO1–melanocortin pathways.

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