Fig. 10: HPV18 E7-mediated upregulation of TAZ expression and activity in cervical cancer. | Nature Communications

Fig. 10: HPV18 E7-mediated upregulation of TAZ expression and activity in cervical cancer.

From: The Hippo pathway transcription factors YAP and TAZ play HPV-type dependent roles in cervical cancer

Fig. 10: HPV18 E7-mediated upregulation of TAZ expression and activity in cervical cancer.The alternative text for this image may have been generated using AI.

The HPV18 E7 oncoprotein activates the ERK1/2 MAPK pathway resulting in activation of the SP1 transcription factor, which drives the increased expression of TAZ. Subsequently TAZ is responsible for a transcriptional programme necessary for the increased proliferation, migration and invasion observed in HPV18-positive cancer cells and this is partially dependent on the actions of the TAZ target TOGARAM2. Figure 10 was created with Biorender.com released under a Creative Commons Attribution-NonCommercial 4.0 International License.

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