Fig. 6: YAP or a TAZ mutant defective in TEAD binding cannot rescue the loss of proliferation in TAZ KD HeLa cells. | Nature Communications

Fig. 6: YAP or a TAZ mutant defective in TEAD binding cannot rescue the loss of proliferation in TAZ KD HeLa cells.

From: The Hippo pathway transcription factors YAP and TAZ play HPV-type dependent roles in cervical cancer

Fig. 6: YAP or a TAZ mutant defective in TEAD binding cannot rescue the loss of proliferation in TAZ KD HeLa cells.The alternative text for this image may have been generated using AI.

A Representative western blots from TAZ KD HeLa cell lysates transfected with pcDNA3, FLAG-TAZ, FLAG-YAP, FLAG-TAZ TEAD binding mutant and FLAG-TAZ S89D, probed for TAZ, FLAG and the loading control GAPDH (n = 3). B Growth curve analysis of TAZ KD HeLa cell lysates transfected with either pcDNA3, FLAG-TAZ, FLAG-YAP, FLAG-TAZ TEAD binding mutant and FLAG-TAZ S89D (n = 3). Colony formation assay (C) or soft agar assay (D) of TAZ KD HeLa cells transfected with pcDNA3, FLAG-TAZ, FLAG-YAP, FLAG-TAZ TEAD binding mutant or FLAG-TAZ S89D (n = 3). Statistical analysis of each condition is compared to each TAZ KD cell line. Error bars represent the mean +/- standard deviation of a minimum of three biological repeats. *P < 0.05, **P < 0.01, ***P < 0.005 (two-tailed, unpaired Student’s t-test). Source data are provided as a Source Data file.

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