Fig. 6: Brain tissue repair of TBI mice after treatment with nanopatch-wrapped NSCs that are individually stimulated by a rotating magnetic field.
From: Wrapping stem cells with wireless electrical nanopatches for traumatic brain injury therapy
a Digital pictures of the mice brain in Sham, TBI, TBI+NSCs, TBI+NSCs+MF, TBI+NSCs+Nanopatch, and TBI+NSCs+Nanopatch+MF groups at day 28. b Percentage of tissue loss in injured site obtained by referring to the pictures in a. Data represent six independent experiments and are presented as the mean ± standard deviation, as analyzed by a one-way ANOVA, with Tukey’s multiple comparisons test (***p < 0.001 compared to the TBI group). c Nissl staining of sectioned brain tissues of the mice in Sham, TBI, TBI+NSCs, TBI+NSCs+MF, TBI+NSCs+Nanopatch, and TBI+NSCs+Nanopatch+MF groups at day 28. d Immunofluorescence images of DCX of sectioned brain tissues of the mice in Sham, TBI, TBI+NSCs, TBI+NSCs+MF, TBI+NSCs+Nanopatch, and TBI+NSCs+Nanopatch+MF groups at day 28. DCX was stained into green. The cell membrane was pre-stained with PKH 26 to red. The nuclei were labeled with DAPI. e Immunofluorescence images of NeuN of the sectioned brain tissues of the mice in Sham, TBI, TBI+NSCs, TBI+NSCs+MF, TBI+NSCs+Nanopatch, and TBI+NSCs+Nanopatch+MF groups at day 28. NeuN was stained into green. The cell membrane was pre-stained with PKH 26 to red. The nuclei were stained into blue by DAPI.
