Fig. 2: Modules inferred from multiplexed brains.

A Intra-Compound Area (intra-CA) consistency. Left, box plot of the intra-CA consistencies for 13 compound areas in the brain (color-coded). Right, the 13 compound areas in CCFv3 atlas. A compound area is a super-region composed of functionally correlated CCFv3 regions. Sample size: CBN, 4; CBX, 14; CTXsp, 7; HPF, 15; HY, 44; Isocortex, 43; MB, 39; MY, 44; OLF, 11; P, 26; PAL, 9; STR, 14; TH, 44. B Horizontal projections on the CCFv3 template of regions with a Spearman correlation coefficient of at least 0.5 with the target region (specified at the top of each image). Each image is accompanied by a box plot that shows the distribution of the pairwise correlations between these regions and the target region, with the box colored by CA as in (A). Region sets are categorized as intra-CA if all regions are within the same compound area, and cross-CA if they span across at least two compound areas. The first 66 region sets (out of 313) are displayed. C Whole-brain co-occurrence modules. Left, circular heatmap representing the neurite density distribution for each CCFv3 brain region (N = 314) as radial 191-element vectors (number of brain images). The dendrogram shows how brain regions cluster to form modules. Labels for each region are specified on two outer layers of the graph, with corresponding compound areas are labeled in the colored circle. Right, tightly inter-correlated modules, with modular consistencies (pairwise Spearman correlations) shown in the box plots on the top of the brains. Source data are provided as a Source Data file. Box plot: edges, 25th and 75th percentiles; central line, the median; whiskers, 1.5× the interquartile range of the edges; dots, outliers.