Fig. 5: Lef treatment alters gut microbial abundance and community structure in PD1 inhibitor-treated mice. | Nature Communications

Fig. 5: Lef treatment alters gut microbial abundance and community structure in PD1 inhibitor-treated mice.

From: Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice

Fig. 5: Lef treatment alters gut microbial abundance and community structure in PD1 inhibitor-treated mice.The alternative text for this image may have been generated using AI.

A Goods coverage index of dilution curves (n = 4). B Simpson’s index, in response to α-diversity of the flora (n = 4). For the box plots, the boxes extend from the first to the third quartile (25th to 75th percentiles), with the center line indicating the median and analyzed using one-way ANOVA followed by Tukey post hoc test (two-sided). C Principal coordinate analysis (PCoA), in response to β-diversity of the flora (n = 4) (ADONIS test: αPD1 verse IgG, p = 0.032; αPD1 verse αPD1+Lef, p = 0.024). D Heatmap of clustering of relative abundance of the flora at the phylum level (n = 4). E Sankey diagram illustrating the dynamic shifts in microbial populations among different groups in response to treatments (n = 4). F Linear discriminant analysis effect size (LEfSe) analysis of the αPD1 group versus the αPD1+Lef group (LDA threshold = 2.0) (n = 4). G Pairwise Spearman rank correlation heatmap for the analysis of the relationship between genus-level flora and cardiac function (n = 4). Data are shown as the mean ± SEM.

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