Fig. 3: Substrate scope of catalytic asymmetric formal (4 + 5) cycloaddition. | Nature Communications

Fig. 3: Substrate scope of catalytic asymmetric formal (4 + 5) cycloaddition.

From: Atroposelective construction of axially chiral alkenylindole-fused nine-membered rings via catalytic asymmetric formal (4 + 5) cycloaddition

Fig. 3: Substrate scope of catalytic asymmetric formal (4 + 5) cycloaddition.The alternative text for this image may have been generated using AI.

Reaction conditions: 1 (0.1 mmol), 2 (0.2 mmol), (R)−4j (30 mol%), DCE (1 mL), 3 Å MS (100 mg), and 30 °C for 5 h. Isolated yields were provided, and ee values were determined using HPLC. a35 mol% (R)−4j.

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