Fig. 5: D10 and D2 amyloid fibrils feature conserved structural elements. | Nature Communications

Fig. 5: D10 and D2 amyloid fibrils feature conserved structural elements.

From: Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration

Fig. 5: D10 and D2 amyloid fibrils feature conserved structural elements.The alternative text for this image may have been generated using AI.

a, b Secondary structure of ordered fibril cores of WT D10-NT polymorph-1 (a) and D2-NT (b) showing the intra-molecular (D10-NT) vs. inter-molecular (D2-NT) packing arrangement of strands 1 and 3. Individual protofilaments (PFs) are shown in tan, blue, salmon, and green. c, d Overlay of D10-NT and D2-NT structures, highlighting the similar conformations of the N-terminus of strand-1 (D10 residues G43-T51; D2 residues G54-T62) and the C-terminus of strand-3 (D10 residues A68-G75; D2 residues A79-G86) and of their detailed packing arrangement. e Overlay of the V55-V57 VAV motif from all three WT D10-NT polymorphs with the corresponding V66-V68 VAV motif in the WT D2-NT structure (D10-NT polymorph-1, purple; D10-NT polymorph-2, pale green; D10-NT polymorph-3, wheat; D2-NT, salmon).

Back to article page