Fig. 3: Prediction results for the external test set.
From: Peripheral blood DNA methylation predicts the early onset of primary tumor in TP53 mutation carriers
A ROC curve for the validation cohort. TP true positive, TN true negative, FN false negative, FP false positive, AUROC area under the receiver operator characteristic curve. B Predicted probability of early cancer onset on the test set for patients with cancer, using a decision boundary of 0.34. The number beside the falsely predicted patients indicates the true age of cancer onset. C Predicted probability of early cancer onset for the null cohort (patients without cancer). The number beside the falsely predicted patients indicates the age of the sample collection. Red = optimized decision threshold, blue = optimal sensitivity. Source data are provided as a Source Data file.
