Fig. 6: Data-to-decision pipeline.
From: Peripheral blood DNA methylation predicts the early onset of primary tumor in TP53 mutation carriers
Our pipeline starts with the blood draw in the clinic, followed by DNA methylation profiling, which is input for a machine learning model that predicts the probability of cancer occurrence before six years of age. The prediction can then be used to personalize cancer surveillance for LFS patients into low, standard (Toronto), or high intensity surveillance protocols.
