Fig. 4: Biocompatibility and in vivo biodegradability of the BioUCT.
From: Biodegradable ultrasound contrast tape for tracing intestinal motility
a, b Fluorescence images of live (green)/dead (red) HCMECS with and without the BioUCT for 21 days. The scale bar is 50 μm. b The ATP quantification of HCMECS cultured with and without the BioUCT for 21 days. Data are presented as mean ± SD. Each data point represents the mean of n independent samples (n = 6). Error bars indicate the ± SD of ATP measurement. c In vivo biodegradation images of the BioUCT within 12 weeks (upper images). The scale bar is 1 cm. Masson’s trichrome staining of paraffin sections of the implant and surrounding tissues (bottom images). The scale bar is 2 mm. d Weight ratio of the BioUCT within the in vivo biodegradation process. Data are presented as mean ± SD. Each data point represents the mean of n independent samples (n = 3). Error bars indicate the ± SD of the weight ratio. e, f Results of blood count (e) and blood chemistry (f) tests over 12 weeks after the implantation of BioUCT in rats. The BioUCT shows no statistical difference compared to the control group. Data are presented as mean ± SD. Each data point represents the mean of n independent samples (n = 3). Error bars indicate the ± SD of test results. g Results of paraffin sections for H&E staining. Vital organs of rats showed no obvious abnormalities 12 weeks after implantation. The scale bar is 200 μm.
