Fig. 3: Reduced Th1 responses in Mtb-infected mice followed by gemcitabine (Gem) treatment. | Nature Communications

Fig. 3: Reduced Th1 responses in Mtb-infected mice followed by gemcitabine (Gem) treatment.

From: Mycobacterium tuberculosis-specific T cells restrain anti-cancer drug-induced neutrophilic lung inflammation in tuberculosis

Fig. 3: Reduced Th1 responses in Mtb-infected mice followed by gemcitabine (Gem) treatment.The alternative text for this image may have been generated using AI.

A, B The frequencies and numbers of ESAT64-17:I-A(b)- or Ag85B280-294:I-A(b)-specific CD4+ T cells identified by tetramer staining were analyzed by flow cytometry. The numbers in the plots indicate the percentage of tetramer-positive cells among CD4+ T cells (n = 4, 5). The graph shows the mean ± SD. Data were analyzed by two-tailed unpaired t-test. C–E The frequencies and numbers of IFN-γ- and TNF-producing CD4+ T cells were analyzed by flow cytometry (n = 4, 5). The graph shows the mean ± SD. Data were analyzed by two-tailed unpaired t-test. **p < 0.01, ***p < 0.001, and ****p < 0.0001 between group. A–E The data are representative of at least two independent experiments. Source data are provided as a Source Data file.

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