Fig. 5: Effect of the juxtamembrane domain on EGFR dimerization in Lo and Ld phase membranes with PI(4,5)P2 molecules present in the inner leaflet. | Nature Communications

Fig. 5: Effect of the juxtamembrane domain on EGFR dimerization in Lo and Ld phase membranes with PI(4,5)P2 molecules present in the inner leaflet.

From: A Pseudomonas aeruginosa quorum-sensing inducer controls lung permeability in establishing chronic infection via EGFR

Fig. 5: Effect of the juxtamembrane domain on EGFR dimerization in Lo and Ld phase membranes with PI(4,5)P2 molecules present in the inner leaflet.The alternative text for this image may have been generated using AI.

A, B Time sequences of simulated snapshots depicting the states of EGFR containing juxtamembrane and transmembrane domains in the Lo (A) and Ld (B) phase membranes. The GxxxG-like motifs participating in the dimerization are displayed as green beads. PI(4,5)P2 molecules are displayed in yellow. The right panel of each figure shows an enlarged image illustrating interactions between juxtamembrane domains of EGFR and PI(4,5)P2 in the inner leaflet. Time evolutions of the distance between GxxxG-like motifs of EGFR in Lo (C) and Ld (D) phase membranes (red lines). The distances between juxtamembrane domains are also displayed (blue lines). Residue contact maps of EGFR in Lo (E) and Ld (F) phase membranes. Transmembrane and juxtamembrane domains are separated by dashed lines. Average interaction energies between transmembrane domains (G)(n = 30,30,30,30) and juxtamembrane domains (H) (n = 30,30,30,30) of EGFR in Lo and Ld phase membranes. Data are as the mean ± SD. Source data are provided as a Source Data file.

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