Fig. 7: 3oc12-EGFR maintains epithelial barrier through influencing tight junction protein expression. | Nature Communications

Fig. 7: 3oc12-EGFR maintains epithelial barrier through influencing tight junction protein expression.

From: A Pseudomonas aeruginosa quorum-sensing inducer controls lung permeability in establishing chronic infection via EGFR

Fig. 7: 3oc12-EGFR maintains epithelial barrier through influencing tight junction protein expression.The alternative text for this image may have been generated using AI.

A 3oc12 inhibits 4KD and 10 KD FITC-Dextran passing through the epithelial cell paracellular pathway (n = 4 per group). B 3oc12 increases the transepithelial electrical resistance of A549 monolayer cells (n = 4 per group). C 3oc12 induced multiple tight junction protein upregulation on mRNA level (n = 3 or 4 per group). D The Micro-CT of lung images in ΔlasI and ΔlasR+lasI strain infected mice (n = 4 per group). E The H&E staining of lung tissue from ΔlasI or ΔlasR+lasI strains infected mice. Data are representative of three independent experiments and are presented as the mean ± s.e.m, **P < 0.01, ***P < 0.001, ****P < 0.0001. Two-tailed unpaired Student’s t-tests were used to analyze data. Source data are provided as a Source Data file.

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