Fig. 3: Naproxen displaces tryptophan from albumin binding.
From: Depression of tryptophan may contribute to adverse effects of naproxen
A Percentage of plasma tryptophan bound to albumin in volunteers (n = 15 per group; n denotes biological replicates) treated with placebo, celecoxib, or naproxen was analyzed using a two-sided Friedman test and Dunn’s multiple correction; Placebo vs. Naproxen (p = 0.003), Celecoxib vs. Naproxen (P = 0.0185). B Free tryptophan levels in the buffer chamber of the RED plate for placebo, celecoxib, and naproxen (n = 15/group, n denotes biological replicates) were analyzed using the two-sided Friedman test with Dunn’s correction; placebo vs. naproxen (P = 0.0105), celecoxib vs. naproxen (P = 0.0057). C Spearman correlation of plasma naproxen and tryptophan in healthy volunteers, with the color bar indicating correlation coefficient r (P = 0.039). The data are expressed as mean ± SD. * Designates statistical significance, ** p ≤ 0.01.
