Fig. 3: Distribution of cognitive function scores and cortical thickness stratified by CSF NPTX1 and NPTXR tertiles across the AD continuum in CANDI cohort.

The box plots depict the median (horizontal bar), interquartile range (IQR, hinges), and the whiskers indicate the minimum and maximum values. n = 255 (NPTXR), n = 183 (NPTX1). P-values (two-sided) were assessed by a one-way analysis of covariance (ANCOVA), adjusting for age, sex, educational level, Aβ42/Aβ40, pTau181 and apolipoprotein E (APOE)-ε4.