Extended Data Fig. 5: Phylogenetic analyses of enzymes and whole proteome from H. umbraculigerum and different plant species. | Nature Plants

Extended Data Fig. 5: Phylogenetic analyses of enzymes and whole proteome from H. umbraculigerum and different plant species.

From: Parallel evolution of cannabinoid biosynthesis

Extended Data Fig. 5: Phylogenetic analyses of enzymes and whole proteome from H. umbraculigerum and different plant species.The alternative text for this image may have been generated using AI.

Phylogenetic analysis of a. acyl-activating enzyme (AAE), b. polyketide synthase (PKS) and c. prenyl transferase (PT) proteins from H. umbraculigerum and other plants. Full list of protein IDs is available in Supplementary Table 15. Bootstrap values are indicated at the nodes of each branch. The selection of the proteins was based on a. Arabidopsis thaliana enzymes44 or b.,c. functionally tested enzymes22,45. Clades according to substrates or functionalities are marked by different colors. None of the active H. umbraculigerum enzymes clustered with any of the known Cannabis proteins. d. Phylogenetic relationship between Arabidopsis thaliana, Solanum lycopersicum, Helianthus annuus, Lactuca sativa, Cannabis sativa and Helicrysum umbraculigerum illustrate the evolutionary distance between the last two species. The tree was constructed based on the whole proteomes of each species using the word-based software Prot-SpaM.

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