Fig. 4: Bacterial functional profiling of the vaginal microbiome (VM).
From: Metagenomic insight into the vaginal microbiome in women infected with HPV 16 and 18
The volcano plots displaying log2 fold change differences in KEGG orthologs (KOs) in (a) group 1, b group 2, and c group 3. Points in blue indicate KOs which were differentially abundant in other HR-HPV, and points in red in HPV 16/18, respectively. Non-metric multidimensional scaling (NMDS) of KOs composition in (d) group 1, e group 2, and f group 3, based on the Bray–Curtis dissimilarities distance matrix. g Bar charts illustrating differentially abundant KEGG pathways across each disease group (log2 fold change >1 or <-1, p < 0.05, DESeq2) between HPV 16/18 and other HR-HPV types. Log2 fold change values are used to denote significant enrichment, with positive values (red bars) indicating enrichment in HPV 16/18 and negative values (blue bars) indicating enrichment in other HR-HPV types. h Differences in key functions associated with the metabolism of glycogen and mucin, two abundant host resources in the vagina. The boxplot displays the combined abundance of the specified enzymes with normalized square root transformation. Significant differences between groups are indicated (*p < 0.05 and •p < 0.1).
