Fig. 4: Dynamic ctDNA/CTCs analysis, tumor DNA detection in surgical tissue, and PCR prediction model.
From: Increased blood draws for ultrasensitive ctDNA and CTCs detection in early breast cancer patients
a Tumor DNA detection in surgical specimens. b ctDNA identification in pre-treatment plasma. c ctDNA dynamics during NAC, including MGE change. Red dots represent median. d ROC curves for NAC response prediction using MGE (left) and in silico cross validation (right). In the box-and-whiskers plots, the median is illustrated along with bars depicting the maximum and minimum values (n = 7 for PCR, n = 13 for no PCR). ctDNA circulating tumor DNA, CTCs circulating tumor cells, NAC neoadjuvant chemotherapy, PCR pathological complete response, MGE mutant genomic equivalents, ROC Receiver operating characteristic, AUC Area under the ROC Curve.
