Fig. 3: Evaluation of tumor size monitoring system ex vivo and in vivo. | npj Flexible Electronics

Fig. 3: Evaluation of tumor size monitoring system ex vivo and in vivo.

From: Fully implantable and battery-free wireless optoelectronic system for modulable cancer therapy and real-time monitoring

Fig. 3: Evaluation of tumor size monitoring system ex vivo and in vivo.The alternative text for this image may have been generated using AI.

a Pictures of the device’s LED probe inserted into the tumor, the mouse model after device subcutaneously implanted, and wireless operation of the device after implantation. b Optical simulation results for the amount of light received by the phototransistor according to the size of the tumor. Scale bar, 2 mm. c The light distributions reaching each position inside the phototransistor derived from the optical simulation results. d Circuit diagram expressing how the device measures the amount of light in an in vivo environment. e Ex vivo experiments measuring phototransistor voltage (VPD) values according to tumor size. Three devices with different insertion sites of tumors were exploited. Scale bar, 1 cm. f VPD and tumor volume measured during the 3-week in vivo experiment. (n = 4). g Images of tumor size change in vivo over 3 weeks for M3.

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