Table 3 Spearman’s correlation coefficients among specific gut bacteria and predicted genes related to uremic toxin synthesis pathways in the L. acidophilus KBL409 group
Genus | Gene (encoded protein) | Coefficient | P-value |
|---|---|---|---|
Blautia | aroF, aroG, aroH (3-deoxy-7-phosphoheptulonate synthase) | 0.2587 | 0.0331 |
tyrB (aromatic amino acid transaminase) | 0.3151 | 0.0089 | |
aroD (3-dehydroquinate dehydratase I) | 0.4186 | 0.0004 | |
Butyricicoccus | pheA2 (prephenate dehydratase) | 0.2395 | 0.0492 |
aroA1, aroA (chorismate mutase) | 0.2457 | 0.0434 | |
aroD (3-dehydroquinate dehydratase I) | 0.2564 | 0.0348 | |
pheC (cyclohexadienyl dehydratase) | 0.2743 | 0.0236 | |
tyrB (aromatic amino acid transaminase) | 0.3663 | 0.0021 | |
Lachnospiraceae UCG-004 | aroD (3-dehydroquinate dehydratase I) | 0.3205 | 0.0077 |
trpA (tryptophan synthase alpha chain) | 0.3312 | 0.0058 | |
trpB (tryptophan synthase beta chain) | 0.3349 | 0.0052 | |
kynB (arylformamidase) | 0.3549 | 0.0030 | |
pheC (cyclohexadienyl dehydratase) | 0.3804 | 0.0014 | |
Megamonas | trpB (tryptophan synthase beta chain) | 0.4119 | 0.0005 |
trpG (anthranilate synthase component II) | 0.4186 | 0.0004 | |
pheA2 (prephenate dehydratase) | 0.4318 | 0.0002 | |
kynB (arylformamidase) | 0.4383 | 0.0002 | |
tyrB (aromatic amino acid transaminase) | 0.5455 | <0.0001 |
