Table 2 Mucosal anti-gp140 response rates are significantly increased vs. anti-gp120 and gp41 responses in all mucosal compartments.

From: Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans

 

Rate (%)

P-value

PFWERa

gp120 vs. gp140

 Cervical sponge

48 vs. 71

0.0001

0.0010***

 Rectal sponge

33 vs. 52

0.0002

0.0015**

 Saliva

24 vs. 39

<0.0001

0.0005***

 Seminal plasma

44 vs. 76

<0.0001

<0.0001***

gp120 vs. gp41

 Cervical sponge

48 vs. 51

0.8145

>0.9999

 Rectal sponge

33 vs. 33

>0.999

>0.9999

 Saliva

24 vs. 27

0.4328

>0.9999

 Seminal plasma

44 vs. 44

>0.9999

>0.9999

gp140 vs. gp41

 Cervical sponge

71 vs. 51

0.0005

0.0024**

 Rectal sponge

52 vs. 33

0.0002

0.0015**

 Saliva

39 vs. 27

0.0017

0.0070**

 Seminal plasma

76 vs. 44

<0.0001

<0.0001***

  1. Bold values are statistically significant.
  2. *PFWER ≤ 0.05; **PFWER ≤ 0.01; ***PFWER ≤ 0.001.
  3. aPFWER is the adjusted P-value for multiple comparisons to control the family-wide type I error rate.
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