Extended Data Fig. 1: Spectral responses of OCC-DNAs to a small set of HGSOC and benign serum samples.

Four spectral parameters –intensity and wavelength changes of the E11 and E11- peaks– were extracted from fluorescence spectra of four serum samples in each group. Each sample was measured in triplicate. Horizontal lines denote the median. Six OCC-DNA nanosensors, with p-values of the spectroscopic features lower than 0.10, were selected for the sensor array.