Extended Data Fig. 3: The AP-1 pathway is modulated by matrix mechanics. | Nature Biomedical Engineering

Extended Data Fig. 3: The AP-1 pathway is modulated by matrix mechanics.

From: Generation of functionally distinct T-cell populations by altering the viscoelasticity of their extracellular matrix

Extended Data Fig. 3: The AP-1 pathway is modulated by matrix mechanics.The alternative text for this image may have been generated using AI.

a, b. AP-1 pathway analysis was performed on enriched cNMF modules from Fig. 3. a. Relative significance of AP-1 related genes in cNMF modules, showing significant AP-1 enrichment in Module 5. b. Violin plots comparing expression levels of Module 5 (AP-1 Module) for T cells with shared TCR clonotypes in tumours, adjacent normal tissues and blood for NSCLC, liver cancer and colorectal cancer. P-values were determined by performing two-tailed one-way Anova. c, d. AP-1 pathway analysis was performed on cNMF modules generated from the indicated fibrosis datasets. c. Relative significance of AP-1 related genes in cNMF modules. d. Violin plots comparing the expression levels of the top AP-1 module in CD8+ T cells derived from healthy and fibrotic tissues for each fibrosis study. e. Violin plots comparing expression levels of our in vitro generated AP-1 Module in CD8+ T cells derived from healthy and fibrotic tissues for the same datasets. P-values were determined by using the Wilcoxon Rank Sum test.

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