Extended Data Fig. 9: T and NK cell activation at 3 days post-infection in the IC-LOC. | Nature Biomedical Engineering

Extended Data Fig. 9: T and NK cell activation at 3 days post-infection in the IC-LOC.

From: An immune-competent lung-on-a-chip for modelling the human severe influenza infection response

Extended Data Fig. 9: T and NK cell activation at 3 days post-infection in the IC-LOC.The alternative text for this image may have been generated using AI.

(a) Representative flow cytometry plots showing levels of activation markers (CD25, CD69, HLA-DR, IFN-γ, Granzyme B) in CD8 T cells from uninfected (-H1N1) and infected (+H1N1) IC-LOC devices. (b) Quantification of activation markers on CD4 + T cells, (c) CD8 + T cells, and (d) CD56 + NK cells from uninfected and infected IC-LOC devices. N = 6 samples, with each sample comprised of two pooled devices from the same immune cell donor across at least 2 independent experiments. Statistical significance determined via two-tailed unpaired t-test, with error bars showing S.E.M.

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