Extended Data Fig. 9: High ATF4 levels correlate with increased COL1 expression on human melanoma and pancreatic tumours. | Nature Cell Biology

Extended Data Fig. 9: High ATF4 levels correlate with increased COL1 expression on human melanoma and pancreatic tumours.

From: A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

Extended Data Fig. 9: High ATF4 levels correlate with increased COL1 expression on human melanoma and pancreatic tumours.The alternative text for this image may have been generated using AI.

a, Pearson correlation between the ISR target signature and COL1A2, FAP and PDGFRβ in Skin Cutaneous Melanoma (SKCM) and Pancreatic adenocarcinoma (PAAD). The linear regression lines along with 95% confidence intervals (shaded regions) are shown. b, Pearson correlation between randomly selected genes and COL1A1 in Skin Cutaneous Melanoma (SKCM) and Pancreatic adenocarcinoma (PAAD). The linear regression lines along with 95% confidence intervals (shaded regions) are shown. c, Representative images from immunohistochemical staining for COL1 and ATF4 of human melanoma tissues d, Pearson correlation between the % ATF4 area and % COL1 area in primary group from the human melanoma tissue array. e, Pancreatic adenocarcinoma tissue array containing sections from 24 tumours were stained for COL1 (upper panel) and ATF4 (lower panel) proteins. f, Representative images from immunohistochemical staining for COL1 and ATF4 of human pancreatic adenocarcinoma tissues. g, Pearson correlation between the % ATF4 area and % COL1 area in all samples from e and h, in grade 2 (left) and grade 3 (right) groups.

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