Extended Data Fig. 9: Plasma concentration–time curves for Y180 in mice. | Nature Microbiology

Extended Data Fig. 9: Plasma concentration–time curves for Y180 in mice.

From: An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron

Extended Data Fig. 9: Plasma concentration–time curves for Y180 in mice.The alternative text for this image may have been generated using AI.

The mean plasma concentration-time curves of Y180 (p.o. 150 mg/kg) in mice (n = 3). The EC50 and EC90 values of Y180 were calculated from the cell-based antiviral activity data obtained with VeroE6-TMPRSS2 cells infected with SARS-CoV-2 strain B.1.1.7 (black dashed lines) or B.1.617 (blue dashed lines). Data are shown as mean ± SD.

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