Extended Data Fig. 10: Expression level of BAZ2B and EHMT1 correlates positively with the progression of Alzheimer’s disease in humans.
From: Two conserved epigenetic regulators prevent healthy ageing
a, Expression level of BAZ2B (left) and EHMT1 (right) at different Braak stages in the prefrontal cortex of brains with Alzheimer’s disease. b, Expression level of BAZ2B (left) and EHMT1 (right) at different stages of frontal atrophy in the prefrontal cortex of brains with Alzheimer’s disease. c–e, Correlations between the expression levels of BAZ2B (x-axes) and selected nuclear genes (encoding mitochondrial proteins; y-axes) in the prefrontal cortex of brains with Alzheimer’s disease. f–h, Correlations between the expression levels of EHMT1 (x-axes) and selected nuclear genes (encoding mitochondrial proteins; y-axes) in the prefrontal cortex of brains with Alzheimer’s disease. In a–h, expression values (n = 390 samples) of examined genes are from the dataset GSE44772, using Pearson’s r correlation coefficient for statistical testing. i, Proposed working model for the epigenetic regulation of mitochondrial function and healthy ageing.
