Extended Data Fig. 6: Species dominating the Bacteroides fraction in the different enterotypes of the non-statin-medicated BMIS cohort.
From: Statin therapy is associated with lower prevalence of gut microbiota dysbiosis
The top associations with the Bact2 enterotype—with the proportions they contribute to the total fraction shown in the ring chart—were the depletion in B. caccae (n = 768 biologically independent samples, Kruskal–Wallis, Padj = 1.3 × 10−15) and B. cellulosilyticus (n = 768 biologically independent samples, Kruskal–Wallis, Padj = 5.3 × 10−13) when compared with the Rum, Prev and Bact1 enterotypes, and the enrichment in B. fragilis (n = 768 biologically independent samples, Kruskal–Wallis, Padj = 3.5 × 10−11; Supplementary Table 11). Species were defined by species-level annotation of metagenomic species, and their proportional abundances were defined relative to the genus abundance. Samples for which the genus had a low total abundance (below the 20% quantile for all species belonging to the top 10 genera) were excluded from the analysis (n = 768 biologically independent samples were included). Adjustment for multiple testing (Padj) was performed using the Benjamini–Hochberg method.
