Extended Data Fig. 6: Structural comparison of GAT1 (green) with GlyT1 (blue) and SERT (pink) inward-open structures.

a, Superposition of overview models between three structures. b, Focus on the intracellular gate, showing differences in TM6b, TM7, TM1a and TM5. c–e, Minor differences between GAT1, GlyT1 and SERT in TM12, TM9, TM10 and TM8 with respective residues highlighted in stick representation: G457 highlights the unique residue in GAT1, potentially leading to additional flexibility of TM10. The interacting residues between ibogaine and SERT TM8 A441-G442-L443 show a subtle helix break, which is unique among the compared sequences and structures.