Extended Data Fig. 2: Somatic driver mutations in 183 prostate cancer patients of different ancestries.

The covariates on the right show the total number of altered samples for different mutational types. a, Search of the top 300 driver genes altered in primary prostate tumours among 183 specimens. Only driver genes discovered in PCAWG and this study, present in more than six patients or significantly different between Africans and Europeans are chosen for plotting. The top barplot shows the distribution of the number of prostate cancer drivers and/or that of PCAWG. The heatmap shows drivers found in this study (rows) for each patient (columns). Heatmaps are coloured by mutational type. The dual barplot on the left depicts gene-level comparisons of mutational recurrence directly between Africans and Europeans. Bottom covariates show the clinical features of patients. The percentage of transition/transversion mutations across 183 patients shows 1,364,210 small somatic mutations across chromosomes 1-Y. b, The bottom heatmap shows the top 22 of previously reported coding driver genes in prostate cancer observed in this study^7,8,17,18. The left barplot shows statistical support of recurrence analysis for our study.