Extended Data Fig. 6: Exhausted CD8+ T cells in PDAC tumors express ADRB1.
From: The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion
a, Representative flow cytometry plots depicting ADRB1 expression of different CD8+ T cell subsets in PDAC tumors implanted into wild type B6 mice. Plots are gated on the indicated cell populations and representative of 2 independent experiments. b, Expression analysis of the indicated exhaustion markers in ADRB1high and ADRB1low CD8+ T cells in RNA Seq data generated from 16 human pancreatic cancer samples. Data from GSE155698. Statistics were calculated using a linear mixed model. Boxplots show median. The lower and upper hinges correspond to the first and third quartiles. The upper whisker extends from the hinge to the largest value no further than 1.5 * IQR from the hinge. Two-sided statistical tests were used. **** indicates a p value < 0.0001, ***<0.001, **<0.01, *<0.05.
