Extended Data Fig. 4: Pharmacological blockade of ADRB1 prevents advanced exhaustion differentiation of antigen-specific CD8+ T cells.
From: The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion
a + b, Absolute cell counts of gp33+ CD8+ T cells (a), and of different exhausted subsets of gp33+ CD8+ T cells (b) isolated from the spleens of mice treated with atenolol or control water during chronic infection with LCMV clone 13, assessed at d37 p.i. (n = 7 per group, pooled from 3 independent experiments). Mann-Whitney test. c, Absolute cell counts of cytokine producing cells after antigen-specific stimulation with gp33. Cells were isolated from the spleens of mice treated with atenolol or control water during chronic infection with LCMV clone 13, assessed at d37 p.i. (n = 8 per group, pooled from 3 independent experiments). Mann-Whitney test. Unless otherwise specified, mean ± SEM is indicated in scatter plots. Two-sided statistical tests were used. **** indicates a p value < 0.0001, ***<0.001, **<0.01, *<0.05.
