Extended Data Fig. 2: Ten RHP-P1 (a) and RHP-S1 (b) sequences simulated from RHPapp output.

To simulate RHP sequences, a batch of 10,000 sequences for RHP-P1 and RHP-S1 was generated using RHPapp, from which 10 were randomly sampled for MD simulation. These sequences represent the blockiness or randomness of RHP sequences from the batch. MMA, OEGMA, EHMA, and SPMA are shown in gray, blue, red, and yellow, respectively.