Supplementary Fig. 7: MIA maps of macrophage and dendritic cell subpopulations across PDAC-A tissue. | Nature Biotechnology

Supplementary Fig. 7: MIA maps of macrophage and dendritic cell subpopulations across PDAC-A tissue.

From: Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas

Supplementary Fig. 7: MIA maps of macrophage and dendritic cell subpopulations across PDAC-A tissue.The alternative text for this image may have been generated using AI.

(a) Expression of M1 (top row) and M2 (bottom row) marker genes (two-tailed Student’s t-test, P < 10−5). Center of violin plots show the median expression level, and grey lines show interquartile range. Violin plots for M1 and M2 macrophages represent 19 and 21 data points, respectively. (b) Enrichment of macrophage subpopulations across PDAC-A ST regions. Indicated are the number of genes used for MIA. Values plotted are calculated using the hypergeometric distribution with 19,738 genes in the background. The number of subpopulation and region-specific genes used in the calculation are shown. (c) Expression of dendritic cells A (top panel) or B (bottom panel) marker genes (two-tailed Student’s t-test, P < 10−5). Center of violin plots show the median expression level, and grey lines show interquartile range. Violin plots for A and B dendritic cell subpopulations represent 12 and 33 data points, respectively. (d) Enrichment of dendritic cell subpopulations across PDAC-A ST regions. Indicated are the number of genes used for MIA. Values plotted are calculated using the hypergeometric distribution with 19,738 genes in the background. The number of subpopulation and region-specific genes used in the calculation are shown.

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