Extended Data Fig. 8: Relative contribution of the four mutational signatures in individual t-MN samples. | Nature Genetics

Extended Data Fig. 8: Relative contribution of the four mutational signatures in individual t-MN samples.

From: Clonal evolution of hematopoietic stem cells after autologous stem cell transplantation

Extended Data Fig. 8: Relative contribution of the four mutational signatures in individual t-MN samples.The alternative text for this image may have been generated using AI.

SBS-C was detected in PID0004, PID0007, PID0008 and PID0009. PID0004 received melphalan during induction therapy. PID0008 bone marrow contained myeloma cells, therefore, SBS-C might be derived from myeloma cells treated with melphalan. For PID0007 and PID0009, the exposure to melphalan only occurred during the conditioning therapy, suggesting that t-MN might have arisen from residual bone marrow cells exposed to melphalan conditioning. PID0008 also contained SBS-C, however, the sample also contained persistent myeloma cells, making it difficult to discern whether SBS-C is from t-MN genome or myeloma cell genome.

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