Extended Data Fig. 3: Genomic alterations in de novo UC samples from TCGA. | Nature Genetics

Extended Data Fig. 3: Genomic alterations in de novo UC samples from TCGA.

From: Tamoxifen induces PI3K activation in uterine cancer

Extended Data Fig. 3: Genomic alterations in de novo UC samples from TCGA.The alternative text for this image may have been generated using AI.

(a) CONSORT flow diagram of de novo UC allocation from the TCGA PanCanAtlas. (b) Plot of genomic features, top panel depicts mutation frequency per megabase (Mb); bottom panel depicts significantly mutated genes detected by MutSig2CV (red line, Q < 0.1), ordered by significance; genes significantly mutated in the TA-UC cohort are shown in bold. (c) Amplifications (left, red) and deletions (right, blue) detected by GISTIC. Chromosomal positions from top to bottom; Q-values from left to right (green line, Q < 0.25). Significant peaks are annotated with chromosomal position and candidate cancer genes, where applicable.

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