Extended Data Fig. 1: Characterization of LPS-induced systemic inflammation.
From: Systemic inflammation impairs myelopoiesis and interferon type I responses in humans
a, Box plots of flu-like symptoms, body temperature, and heart rate following intravenous injection of placebo (0.9% NaCl, blue, n = 4) or LPS (2 ng kg−1, red, n = 7) in healthy volunteers. b, Heatmap of log2(fold-change) blood concentrations of cytokines TNF, IL-10, CCL4, CCL3, IL-6, CXCL8, CCL2, IL-1RN following intravenous injection of placebo (0.9% NaCl, n = 4) or LPS (2 ng kg−1, n = 7) compared with baseline (timepoint 0) in healthy volunteers. c, Box plots of absolute number of blood leukocytes, monocytes, lymphocytes and neutrophils following intravenous injection of placebo (0.9% NaCl, blue, n = 4) or LPS (2 ng kg−1, red, n = 7) in healthy volunteers. d, Representative example of flow cytometric analysis of different blood monocyte subsets before (baseline) and at 4 h and d7 following LPS administration (2 ng kg−1). Box plots in a, c shows median, first and third quartiles; whiskers show 1.5x the interquartile range.
