Extended Data Fig. 7: BBB breakdown is independent of amyloid and tau oligomers.
From: Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction
a, CSF sPDGFRβ is increased with impaired cognitive domains, independent of amyloid positivity by PiB-PET; supports Fig. 3d–f. b–c, No differences were observed in CSF Aβ (b) and tau (c) oligomer levels in individuals with 0 or 1+ impaired cognitive domains. d–e, Increases in CSF sPDGFRβ (d) and regional BBB Ktrans in the HC and PHG (e) of individuals with 1+ versus 0 cognitive domain impairment remain significant after statistically controlling for the impact of CSF tau oligomers; supports Fig. 3d–f. a–c, The box and whisker plot lines indicate the median values, the boxes indicate the IQR, and the whiskers indicate the minimum and maximum values. a, Significance tests from ANCOVAs. b–c, Significance by two-tailed Student’s t-test at α = 0.05. d–e, ANCOVA models representing the estimated marginal means ± s.e.m. The brackets denote the sample size (n) in each analysis.
