Fig. 5: Organ-specific ligand–receptor signaling between metastatic tumors and tumor-adjacent tissue macroenvironments.
a, Analysis of bulk RNA-seq showing signaling strengths of incoming and/or outgoing ligand–receptor pairs between tumor and AN (also known as macroenvironmental) tissues in the liver, lung and spleen. Values are row-scaled. b, As in a, except data visualized as chord diagrams and included the brain. Arrows point to the receivers (receptors). c, Immunofluorescent co-staining of IFNκ and IFNAR2 in RAM case-matched brain tumors, AN and NAN tissues (ruler, 50 μm; experiment performed once).
