Extended Data Fig. 4: Identification of APOE ε4 proteins in the dorsolateral prefrontal cortex of individuals with neurodegenerative diseases and non-impaired controls.
From: APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases
APOE ε4 proteins identified using label-free MS from the AMP-AD UPenn Proteomics Study cohort and mutual information. (a,c,e,g,i,k) PCA showing all label-free MS measured proteins in each donor group and no clear clustering across APOE ε4 carriers and non-carriers. (b,d,f,h,j,l) PCA showing only APOE ε4-identified proteins in each donor group, which leads to clustering in each group based on the presence or absence of an APOE ε4 allele. AD: Alzheimer’s disease; ALS: amyotrophic lateral sclerosis; FTD: frontotemporal dementia; PD: Parkinson’s disease; PDD: Parkinson’s disease dementia.
