Extended Data Fig. 4: General translation inhibition in CamK2α principal neurons. | Nature Neuroscience

Extended Data Fig. 4: General translation inhibition in CamK2α principal neurons.

From: Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation

Extended Data Fig. 4: General translation inhibition in CamK2α principal neurons.The alternative text for this image may have been generated using AI.

Blocking protein synthesis in CamK2α principal neurons in LA did not affect acclimation to a novel environment (a), total locomotor activity (b) or thigmotaxis, assessed by % distance traveled in center compared to total distance (c). d) In the elevated plus maze, however, animals with protein synthesis blocked in CamK2α principal neurons exhibited reduced anxiety i.e. increased %open arm duration (*p<0.05) compared to vehicle treated CamK2α iPKR mice and CamK2α wildtype mice even though they make equivalent entries to the open arm (e). n = 4-5 per group. RM Two-way ANOVA for a), One-way ANOVA followed by Bonferroni’s post-hoc test for (b), (c), (d) and (e).

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