Extended Data Fig. 4: Validation of oMN and sMN population by comparing transcriptome profile with reference dataset. | Nature Neuroscience

Extended Data Fig. 4: Validation of oMN and sMN population by comparing transcriptome profile with reference dataset.

From: Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS

Extended Data Fig. 4: Validation of oMN and sMN population by comparing transcriptome profile with reference dataset.The alternative text for this image may have been generated using AI.

(A-B) Heatmap shows differential expression levels of oMN- or sMN-specific genes in sorted HB9::GFP+ and PHOX2B::GFP+ of SOD1A4V and C9ORF72 ALS hiPSC lines (A), or reanalyzed mouse dataset from a previous literature (B). (C) Combined heatmap shows relative expression levels of oMN- or sMN-specific genes in sorted HB9::GFP+ and PHOX2B::GFP+ of SOD1A4V and C9ORF72 ALS hiPSC lines, and reanalyzed mouse dataset from a previous literature.

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