Extended Data Fig. 7: Common alteration of C21H26O3 in multiple ALS lines and direct comparision of altered metabolic metabolites by metabolomics analysis in isogenic control of SOD1A4V and SOD1A4V ALS hiPSC lines. | Nature Neuroscience

Extended Data Fig. 7: Common alteration of C21H26O3 in multiple ALS lines and direct comparision of altered metabolic metabolites by metabolomics analysis in isogenic control of SOD1A4V and SOD1A4V ALS hiPSC lines.

From: Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS

Extended Data Fig. 7: Common alteration of C21H26O3 in multiple ALS lines and direct comparision of altered metabolic metabolites by metabolomics analysis in isogenic control of SOD1A4V and SOD1A4V ALS hiPSC lines.The alternative text for this image may have been generated using AI.

(A-B) Ion count values present commonly down-regulated C21H26O3 metabolic candidate in multiple ALS lines (A) and direct comparison of isogenic control of SOD1A4V and SOD1A4V lines (B) (*P<0.05, ***P<0.001, ****P<0.0001, n.s.: not significant, two-tailed; unpaired student’s t-test; p-values are indicated in each graph; at least n=3 for each lines; technical replicates; n=1 hESC control, n=3 hiPSC control, n=1 isogenic control hiPSC of SOD1A4V, n=6 C9ORF72, n=3 SOD1, n=3 TDP43, n=5 sporadic ALS hiPSC; biological replicates). (C-D) Heatmap shows the lists of selective metabolite candidate in isogenic control of SOD1A4V and SOD1A4V ALS hiPSC lines (n=6 for each group, n means 6 independent differentiation from 2 batch; technical replicates). Error bars: mean ± SEM.

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