Fig. 2: ARG1+ microglia have a site-specific distribution in the brains of P10 and P28 WT mice. | Nature Neuroscience

Fig. 2: ARG1+ microglia have a site-specific distribution in the brains of P10 and P28 WT mice.

From: ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain

Fig. 2: ARG1+ microglia have a site-specific distribution in the brains of P10 and P28 WT mice.The alternative text for this image may have been generated using AI.

a, ARG1+ microglia are found in defined locations in the brain, forming clusters. The largest cluster is found in the BF/vStr (red cluster). Each dot corresponds to a single ARG1+IBA1+ cell (n = 1 animal). Scale bars, x = y = 1,000 μm and z = 5,580 μm (a; P10) and z = 5,845 μm (a; P28). D, dorsal; V, ventral; P, posterior; L, lateral. b, Registration of iDISCO+ to the Allen Mouse Brain map of the BF/striatum (n = 3 P28 male animals). The percentage of area (pixels) that ARG1+ microglia occupy, accompanied by a graphical illustration and absolute number of ARG1+ microglia in each brain area, as quantified by iDISCO+ is shown. Each circle corresponds to one animal. Data are shown as mean ± s.e.m. The schematic in b was adapted from the Allen Brain Institute Reference Atlas (http://mouse.brain-map.org). Source Data Fig. 2b contains definitions for the abbreviations used.

Source data

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