Fig. 5: Arg1 microglial cKO leads to an impaired cognition phenotype in 2- to 3-month-old female mice.
a,b, Strategy for Arg1-cKO and subsequent behavioral studies. c, Percentage of entries in each arm in relation to the percentage of the first session was determined; entries in novel arm, P = 0.0058. d, Short-term memory and long-term memory were expressed as a discrimination index (number novel – number familiar)/(number novel + number familiar) taking into account the training index; long-term memory, P = 0.0148. Each triangle corresponds to one animal; female Arg1-control n = 11 (c) and n = 10 (d) and Arg1-cKO n = 9 (c) and n = 8 (d); male Arg1-control n = 10 (c) and Arg1-cKO n = 6 (c). Data are shown as mean ± s.e.m. Statistically significant differences were determined by two-sided Mann–Whitney U-test (for females Y maze/novel arm) and unpaired two-sided t-tests (for males Y maze/novel arm and females object recognition memory); *P < 0.05 and **P ≤ 0.01.
