Extended Data Fig. 1: Endogenous ISL1 and LHX3 expression decreases with time. | Nature Neuroscience

Extended Data Fig. 1: Endogenous ISL1 and LHX3 expression decreases with time.

From: Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons

Extended Data Fig. 1: Endogenous ISL1 and LHX3 expression decreases with time.The alternative text for this image may have been generated using AI.

a, Endogenous Il1 and Lhx3 expression decrease sharply after their peak at E13.5 (RNAseq data from2; n = 2-3 mice per timepoint; expression for each time point normalized to values at E13.5). b, Endogenous ISL1 and LHX3 are undetectable by immunofluorescence in CHAT+ cells in the L4-L5 ventral horn in untreated animals at P45. Images are maximum intensity projections of 15 z sections taken 3 µm apart. Scale bar represents 20 µM. Similar immunostaining experiments were performed in n = 12 mice.

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