Table 3 Top 100 novel proteins identified in the in-depth RBC membrane and cytoplasmic proteome analyses.

From: Comprehensive Human Red Blood Cell Membrane and Cytoplasmic Proteome Analyses

	Accession	Gene	Description	Membrane extract	Cytoplasmic extract		Accession	Gene	Description	Membrane extract	Cytoplasmic extract
1	P02100	HBE1	Hemoglobin subunit epsilon	1687	6431	51	P68036	UBE2L3	Ubiquitin-conjugating enzyme E2 L3	131	138
2	P68133	ACTA1	Actin, alpha skeletal muscle	5987		52	Q14651	PLS1	Plastin-1	137	54
3	P0CG39	POTEJ	POTE ankyrin domain family member J	3016		53	Q9Y6D5	ARFGEF2	Brefeldin A-inhibited GEP 2	132
4	P68371	TUBB4B	Tubulin beta-4B chain	1039	226	54	P26639	TARS1	Threonine–tRNA ligase 1, cytoplasmic	64	132
5	Q13885	TUBB2A	Tubulin beta-2A chain	880		55	P05388	RPLP0	Large ribosomal subunit protein uL10	128	49
6	P68366	TUBA4A	Tubulin alpha-4A chain	526	157	56	Q9BXJ9	NAA15	N-alpha-acetyltransferase 15	126	87
7	P30046	DDT	D-dopachrome decarboxylase	102	510	57	P54136	RARS1	Arginine–tRNA ligase, cytoplasmic	126	109
8	Q71U36	TUBA1A	Tubulin alpha-1A chain	509		58	Q12792	TWF1	Twinfilin-1	124	9
9	P07205	PGK2	Phosphoglycerate kinase 2	215	472	59	P62837	UBE2D2	Ubiquitin-conjugating enzyme E2 D2	123	34
10	Q15257	PTPA	Serine/threonine-protein phosphatase 2 A activator	183	441	60	P00488	F13A1	Coagulation factor XIII A chain	119
11	Q3LXA3	TKFC	Triokinase/FMN cyclase	424	203	61	Q9NX46	ADPRS	ADP-ribosylhydrolase ARH3	117	66
12	P54577	YARS1	Tyrosine–tRNA ligase, cytoplasmic	414	243	62	Q14667	BLTP2	Bridge-like lipid transfer protein family member 2	117
13	P0DPH8	TUBA3D	Tubulin alpha-3D chain	411		63	P57737	CORO7	Coronin-7	117	54
14	P14868	DARS1	Aspartate–tRNA ligase, cytoplasmic	410	282	64	O94903	PLPBP	Pyridoxal phosphate homeostasis protein	117	55
15	Q9UL18	AGO1	Protein argonaute-1	388		65	Q9BVL4	SELENOO	Protein adenylyltransferase SelO, mitochondrial	117	59
16	Q9Y281	CFL2	Cofilin-2	386	226	66	P47897	QARS1	Glutamine–tRNA ligase	116	26
17	P50502	ST13	Hsc70-interacting protein	251	382	67	Q8IZU0	FAM9B	Protein FAM9B		116
18	Q58FF7	HSP90AB3P	Putative heat shock protein HSP 90-beta-3		372	68	A6NHL2	TUBAL3	Tubulin alpha chain-like 3	111
19	P68032	ACTC1	Actin, alpha cardiac muscle 1		349	69	Q9NWV4	CZIB	CXXC motif containing zinc binding protein	10	111
20	Q53H96	PYCR3	Pyrroline-5-carboxylate reductase 3	347	85	70	Q01546	KRT76	Keratin, type II cytoskeletal 2 oral	109
21	P63241	EIF5A	Eukaryotic translation initiation factor 5A-1	330	339	71	Q8N1F7	NUP93	Nuclear pore complex protein Nup93	109
22	O43681	GET3	ATPase GET3	323	126	72	Q9UQE7	SMC3	Structural maintenance of chromosomes protein 3	109
23	Q9NZN3	EHD3	EH domain-containing protein 3	299	97	73	Q9NVJ2	ARL8B	ADP-ribosylation factor-like protein 8B	107
24	Q13404	UBE2V1	Ubiquitin-conjugating enzyme E2 variant 1	203	292	74	P11172	UMPS	Uridine 5′-monophosphate synthase	107	35
25	Q8N0W3	FCSK	L-fucose kinase	289	57	75	Q13131	PRKAA1	AMPK subunit alpha-1	105	35
26	P60981	DSTN	Destrin	276	161	76	Q9Y3A5	SBDS	Ribosome maturation protein SBDS	105
27	Q15477	SKIC2	Superkiller complex protein 2	276		77	P49959	MRE11	Double-strand break repair protein MRE11	104	50
28	Q6PGP7	SKIC3	Superkiller complex protein 3	271	25	78	Q6PHR2	ULK3	Serine/threonine-protein kinase ULK3	104	17
29	Q08257	CRYZ	Quinone oxidoreductase	262	19	79	Q9Y4B6	DCAF1	DDB1- and CUL4-associated factor 1	103	2
30	P41091	EIF2S3	Eukaryotic translation initiation factor 2 subunit 3	257	130	80	Q5EBM0	CMPK2	UMP-CMP kinase 2, mitochondrial	102	52
31	P48668	KRT6C	Keratin, type II cytoskeletal 6C	255		81	Q58FF3	HSP90B2P	Putative endoplasmin-like protein	102
32	P23381	WARS1	Tryptophan–tRNA ligase, cytoplasmic	105	248	82	P50453	SERPINB9	Serpin B9	61	101
33	Q9HCK5	AGO4	Protein argonaute-4	244		83	Q7Z494	NPHP3	Nephrocystin-3	5	101
34	Q58FG1	HSP90AA4P	Putative heat shock protein HSP 90-alpha A4	213	129	84	Q96L46	CAPNS2	Calpain small subunit 2	98
35	P23258	TUBG1	Tubulin gamma-1 chain	206	26	85	Q5JPE7	NOMO2	BOS complex subunit NOMO2	98
36	P19823	ITIH2	Inter-alpha-trypsin inhibitor heavy chain H2	205		86	Q5T6V5	QNG1	Queuosine 5′-phosphate N-glycosylase/hydrolase	46	96
37	P11488	GNAT1	Guanine nucleotide-binding protein G	194		87	Q9C0E8	LNPK	ER junction formation factor lunapark	94
38	O75155	CAND2	Cullin-associated NEDD8-dissociated protein 2	188		88	P42338	PIK3CB	PI3-kinase subunit beta	94
39	Q15418	RPS6KA1	Ribosomal protein S6 kinase alpha-1	183	99	89	Q8N7R7	CCNYL1	Cyclin-Y-like protein 1	93
40	Q9H3K6	BOLA2	BolA-like protein 2	107	170	90	P13929	ENO3	Beta-enolase	80	93
41	Q9H4B7	TUBB1	Tubulin beta-1 chain	162		91	P29317	EPHA2	Ephrin type-A receptor 2	24	93
42	P68363	TUBA1B	Tubulin alpha-1B chain		162	92	Q8NCW5	NAXE	NAD	14	93
43	Q9GZN8	ADISSP	Adipose-secreted signaling protein	160	117	93	Q16526	CRY1	Cryptochrome-1	92
44	Q86YT6	MIB1	E3 ubiquitin-protein ligase MIB1	154	8	94	O00429	DNM1L	Dynamin-1-like protein	92	9
45	P49589	CARS1	Cysteine–tRNA ligase, cytoplasmic	80	150	95	P31943	HNRNPH1	Heterogeneous nuclear ribonucleoprotein H	91	28
46	Q99598	TSNAX	Translin-associated protein X	115	146	96	O95372	LYPLA2	Acyl-protein thioesterase 2	89	34
47	Q8IYD1	GSPT2	Eukaryotic peptide chain release factor subunit 3b	145	96	97	Q8IZH2	XRN1	5′-3′ exoribonuclease 1	89
48	O95819	MAP4K4	MAPK/ERK kinase kinase kinase 4	145		98	O15357	INPPL1	Inositol polyphosphate phosphatase-like protein 1	88
49	Q9Y530	OARD1	ADP-ribose glycohydrolase OARD1	141		99	Q9GZS3	SKIC8	Superkiller complex protein 8	88	12
50	P02763	ORM1	Alpha-1-acid glycoprotein 1	46	140	100	Q9UKE5	TNIK	TRAF2 and NCK-interacting protein kinase	88

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Table 3 Top 100 novel proteins identified in the in-depth RBC membrane and cytoplasmic proteome analyses.

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