Table 1 Definition of switching.
Type of switch | Switching from original outcome | Primary outcome in trial protocol | Primary outcome in manuscript |
|---|---|---|---|
No Switch | No switching | One primary outcome | Same primary outcome |
Minor switching | Minor switching | Several primary outcome | One primary outcome chosen |
Minor switching | Several general outcome | Primary outcome the first in general list | |
Minor switching | One primary outcome | Reformulated primary outcome | |
Minor switching | Several general outcome | Primary outcome not first in general list | |
Major switching | Major switching | No primary outcome | New primary outcome |
Major switching | Primary outcome reported | Initially secondary outcome as primary outcome | |
Major switching | Primary and secondary outcome reported | Primary outcome not congruent with either primary or secondary outcome |
