Figure 1 | Scientific Reports

Figure 1

From: HDAC4 degradation by combined TRAIL and valproic acid treatment induces apoptotic cell death of TRAIL-resistant head and neck cancer cells

Figure 1The alternative text for this image may have been generated using AI.

Combined TRAIL and VPA treatment induced cytotoxicity in head and neck cancer cell lines. (A) FaDu, HN3 and SNU899 were treated with TRAIL (0.5, 1 µg/ml) and/or VPA (2.5, 5, 10, 20 mM) for 24 h. MTT assay was used to measure cell viabilities. (*p < 0.05; **p < 0.01; ***p < 0.001) (B) HN3 cells were treated with TRAIL (0.5 µg/ml) and VPA (5 mM), and then the cells were stained with annexin V-FITC and propidium iodide and analyzed via flow cytometry. (C) Cell death by combination TRAIL and VPA was determined using a light microscope.

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